Groundbreaking research conducted by a collaborative team from Mount Sinai and Memorial Sloan Kettering Cancer Center has unveiled a novel mechanism by which monoamine neurotransmitters, specifically serotonin, dopamine, and histamine, regulate brain physiology and behavior. This research
The field of drug discovery has long been challenged by the concept of "undruggable" targets—proteins and pathways that are crucial in disease processes but difficult to target with traditional small molecule drugs. One particularly challenging target is β-catenin, a key player in the Wnt/β-catenin
Imagine a world where cancer patients could receive personalized treatment precisely tailored to their unique biological makeup, drastically improving their chances of success. This once-idealistic vision is now becoming a reality with the advent of SCORPIO, an innovative AI-driven tool developed
Glioblastoma, an aggressive and often fatal form of brain cancer, has long posed a formidable challenge to medical professionals. With an average lifespan of 12 to 15 months post-diagnosis and a mere 5% survival rate five years after diagnosis, the need for innovative treatments has never been more
Penn Medicine’s Center for Cellular Immunotherapies (CCI) is at the forefront of revolutionizing cancer treatment through CAR (chimeric antigen receptor) T cell therapy. This innovative approach harnesses the power of the patient’s own immune system to target and destroy cancer cells, offering new
In a transformative study examining the impact of GLP-1 receptor agonist drugs on post-surgical outcomes for diabetic patients, researchers have discovered significant reductions in post-surgical complications when these medications are part of the regimen. Drugs like tirzepatide and semaglutide,
