Scripps Research scientists led a team that reports that it has uncovered key details of an immune-cell process that frequently underlies excessive inflammation in the body. The findings could lead to new ways of preventing and/or treating inflammation-related conditions such as sepsis, arthritis, and coronary artery disease, according to the researchers.
The study “Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation” appears in Nature Communications and shows that a multi-protein “molecular machine” called WASH has an important role in restraining excessive inflammatory activity by neutrophils.
