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Incyte announces agreement to acquire Escient Pharmaceuticals for $750m

April 24, 2024


The deal gives Incyte access to an oral Mas-related G protein-coupled receptor X2 (MRGPRX2) antagonist which, according to the companies, “has the potential to treat multiple mast cell-mediated diseases”, including atopic dermatitis, chronic inducible urticaria and chronic spontaneous urticaria.

Preclinical study results showed that the candidate, EP262, improved atopic dermatitis-like skin lesions and markers of type 2 inflammation, while an early-stage study in healthy volunteers showed it was safe and well tolerated at all tested doses.

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