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Category: Clinical Trials


Clinical Trials, Research and Development

X4 Pharmaceuticals announces positive top-line results for WHIM Syndrome drug

November 30, 2022

Via: Pharmaphorum

WHIM syndrome is a rare, inherited, combined immunodeficiency disease that inhibits the body’s ability to fight infections. In most patients, this is caused by over-signalling of the CXCR4/CXCL12 pathway, resulting in reduced mobilisation and trafficking of white blood cells from […]


Clinical Trials, Research and Development

Early Alzheimer’s Disease Detected by Urinary Biomarker

November 30, 2022

Via: GEN

The results of research headed by a team at Shanghai Jiao Tong University have identified formic acid as a sensitive urinary biomarker that can reveal early-stage Alzheimer’s disease (AD). The findings could potentially pave the way for inexpensive and convenient […]


Clinical Trials, Research and Development

Uncovering How to Target Glioblastoma Cancer Cells

November 30, 2022

Via: GEN

Researchers from Flinders University and the South Australian Health and Medical Research Institute (SAHMRI) have been studying ways to uncover potential new drug therapies for the common and lethal brain cancer, glioblastoma. In a new study, the team discovered that […]


Clinical Trials, Research and Development

Lethal, Tick Borne, Hemorrhagic Fever Virus May Find Treatment in mAbs

November 29, 2022

Via: GEN

As far as emerging, zoonotic, viruses go—Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is one to watch. The disease, which is endemic in Africa, the Balkans, the Middle East, and some Asian countries, is considered a priority pathogen by the World Health […]


Clinical Trials, Research and Development

COVID in Pregnancy Can Vary — Get Vaccinated to Stay Safe

November 28, 2022

Via: Drugs.com

When pregnant women contract COVID-19, one in 10 will have moderate, severe or even critical symptoms, a new study finds. So it’s important they get their COVID vaccines, experts say. “Given that patients in all trimesters of pregnancy are susceptible […]


Clinical Trials, Research and Development

MHRA, NHS England make available new prostate cancer treatment

November 28, 2022

Via: Pharmaphorum

There are over 52,000 cases of prostate cancer each year in the UK alone, with over 15,000 new cases of metastatic prostate cancer confirmed annually. The approval comes after the presentation of data from the ARASENS phase 3 clinical trial […]


Clinical Trials, Research and Development

Lung Cancer Progression Predicted by Tumor Matrix

November 22, 2022

Via: GEN

Squamous cell carcinoma (SqCC) is the second most prevalent type of lung cancer. However, treatment options for these patients remain limited and have remained largely unchanged over decades. Now, a new study by researchers at the Garvan Institute of Medical […]


Clinical Trials, Research and Development

Gut Microbiome Drives Production of Neutrophils after Prolonged Chemotherapy

November 22, 2022

Via: GEN

The results of a study by researchers at Hokkaido University’s Faculty of Medicine have shown how composition of the gut microbiome is crucial to driving a process known as granulopoiesis that replenishes neutrophil counts in the blood of mice following […]


Clinical Trials, Research and Development

Organoid Framework Facilitates Engineering of Self-Organizing Tissues

November 22, 2022

Via: GEN

The complex networks of fluid-filled tubes and loops that exist in human organs have three-dimensional structures whose connections vary, depending on the organ. How these connections and topology develop during the development of an embryo, remains unclear. Now, using tissue […]


Clinical Trials, Industry, Research and Development, Vaccines

Overcoming the challenges of developing vaccines in an accelerated timeframe

November 21, 2022

Via: Pharmaphorum

The world responded to the crisis at unprecedented speed, as leaders and experts focused on different ways to operate and succeed within the constraints of a new dynamic. One standout success we have all benefitted from is vaccine development, with […]


Clinical Trials, Research and Development

Uncommon Antibody Provides Ultrapotent Protection against Zika Virus

November 21, 2022

Via: GEN

In a study published in the journal Cell on November 18, a team led by scientists at Weill Cornell Medicine, and the National Institutes of Health (NIH) have isolated an uncommon and ultrapotent antibody that can neutralize the pathogenic zika […]


Clinical Trials, Research and Development

Alzheimer’s and Down Syndrome Exhibit the Same Amyloid Beta Plaques and Tau Prions, Study Shows

November 21, 2022

Via: GEN

The brains of people with Down syndrome (DS) develop the same neurodegenerative tangles and plaques that are associated with Alzheimer’s disease (AD), and individuals with DS commonly exhibit signs of the neurodegenerative disorder in their forties or fifties. A new […]


Clinical Trials, Research and Development

Machine Learning Helps Predict Response to Immunotherapy

November 18, 2022

Via: GEN

Scientists at the Johns Hopkins Kimmel Comprehensive Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy report that they successfully trained a machine learning algorithm to predict, in hindsight, which patients with melanoma would respond to treatment and which would […]


Clinical Trials, Research and Development

Intestinal C. Difficile Infection Supported by Antibiotic-Resistant Gut Bacteria

November 18, 2022

Via: GEN

Clostridioides difficile is a bacterium that causes severe intestinal illness, but can be difficult to study and treat, and represents a significant public health issue. Studies in mice and in children carried out by researchers at Children’s Hospital of Philadelphia […]


Clinical Trials, Research and Development

Age-Related Macular Degeneration Linked to High-Risk Cardiovascular Disease

November 18, 2022

Via: GEN

A new study from New York Eye and Ear Infirmary of Mount Sinai demonstrates that patients with a specific form of age-related macular degeneration (AMD) may have either underlying heart damage from heart failure and heart attacks, or advanced heart […]


Clinical Trials, Industry, Research and Development, Vaccines

Kids Born by C-Section May Have Weaker Response to Vaccines

November 16, 2022

Via: Drugs.com

Babies born via cesarean section may not mount as strong an immune response after some childhood vaccines compared to babies delivered vaginally, researchers suggest. Antibody levels can be checked in blood or saliva, and babies born vaginally had higher levels […]


Clinical Trials, Research and Development

As resistant tuberculosis rises, GSK says trial backs novel antibiotic

November 16, 2022

Via: Pharmaphorum

The study of GSK3036656 – an inhibitor of the bacterial enzyme leucyl t-RNA synthetase (LeuRS) – showed that 14 days’ treatment with a low once-daily dose showed it was able to kill Mycobacterium tuberculosis in patients with drug-susceptible pulmonary tuberculosis, […]


Clinical Trials, Research and Development

Somatic Cell Copy Number Changes in HNSC Cancer Predict Immunotherapy Response

November 15, 2022

Via: GEN

A study led by researchers at NYU Grossman School of Medicine and UC San Diego Moores Cancer Center has found that patients with head and neck cancer who have more genetic material at a specific region on chromosome 9 in […]


Clinical Trials, Research and Development

Propelling clinical research into the 21st century

November 15, 2022

Via: Pharmaphorum

Thankfully, the world has mostly returned to normal and the virus will hopefully be a thing of the past in the near future. The pandemic leaves myriad economic, social, health, and psychological scars in its wake. It caused intense suffering […]


Clinical Trials, Industry, Research and Development, Vaccines

Sanofi/GSK’s next-generation COVID-19 booster granted EC approval

November 14, 2022

Via: PMLiVE

Shipments of the Beta-targeting booster are ready to be distributed to European countries as per advance purchase agreements, the companies said in a statement, in time for autumn/winter COVID-19 vaccination campaigns. “Today’s approval validates our research in developing a novel […]