Psychiatric disorders already imposed a heavy burden on society before the COVID-19 pandemic. But now that we are dealing with COVID-19-related stress and the direct neuropsychiatric effects of the SARS-CoV-2 virus, the burden is beginning to feel all but crushing. We would welcome therapeutic relief, but so little is available. Why should so few drugs be available in this time of crisis? Until recently, neuropsychiatric drug development looked unpromising. Many pharmaceutical companies had stepped back from developing drugs for historically intransigent indications such as major depressive disorder, Alzheimer’s disease, and schizophrenia.