Category: Clinical Trials

December 16, 2022

Scientists at Scripps Research and Massachusetts Institute of Technology (MIT) have found a clue to the molecular cause of Alzheimer’s disease (AD), which may also explain why women are at greater risk for the disease than men. The team found […]

December 15, 2022

A new study by the University of Colorado Anschutz Medical Campus demonstrates viruses can inflame and disrupt connections between the olfactory system, and the part of the brain associated with memory and learning, which may accelerate the onset of Alzheimer’s […]

December 15, 2022

A study led by researchers at the University of Pennsylvania Perelman School of Medicine has found that some species of gut-dwelling bacteria activate nerves in the gut to promote the desire to exercise. The research found that differences in running […]

December 14, 2022

The two partners have revealed the first clinical data from a phase 2b trial of a personalised vaccine consisting of 34 mRNAs, each targeting mutations – identified by gene sequencing – that are thought to be driving a patient’s cancer. […]

December 13, 2022

Statistics show there are 6.5 billion smartphone users globally in 2022. That means approximately 83% of the world’s population has a smartphone. If researchers leverage these and other wearable devices for BYOD eCOA data collection, it makes the process simpler, […]

December 13, 2022

Cholera is an acute diarrheal illness caused by infection of the intestine with Vibrio cholerae. People can get sick when they swallow food or water contaminated with cholera bacteria. A new study reveals molecules found in mucus can block cholera […]

December 13, 2022

This work is published in Nature, in the paper, “Programming Multicellular Assembly with Synthetic Cell Adhesion Molecules.” “We were able to engineer cells in a manner that allows us to control which cells they interact with, and also to control […]

December 12, 2022

Amphera – a company developing MesoPher cell therapy to treat cancer – has delivered positive results from its phase 2 Reactive trial and phase 2/3 DENIM trial. During the phase 2 Reactive study, patients with resected pancreatic cancer who had […]

December 12, 2022

A research team from the University of Cologne and collaborators has now shown that RNA interference, or RNAi for short, which is known to be a viral defense mechanism, also prevents the overproduction of the body’s own proteins in intestinal […]

December 9, 2022

Gilead placed a major bet on cell therapy with its $12 billion acquisition of Kite in 2017. To the frustration of some investors, the business took several years to ramp up. But sales have substantially grown in recent months. Gilead’s […]

December 6, 2022

While many pieces of the drug development process have digitised to keep pace with the speed of technological advancements, clinical trials continue to lag amidst pharma’s digital transformation. According to Peleg, one of the biggest inefficiencies is in the process […]

December 5, 2022

Prostate cancer is the most frequently diagnosed cancer in men in 112 countries. A vast majority of patients diagnosed with CRPC already present with metastases at the time of diagnosis. Those with metastatic prostate cancer have an estimated 30% chance […]

December 2, 2022

After finding success investing in the more obviously lucrative corners of American medicine — like surgery centers and dermatology practices — private equity firms have moved aggressively into the industry’s more hidden niches: They are pouring billions into the business […]

December 2, 2022

Using data-informed insights derived by effectively implemented datasets, artificial intelligence/machine learning capabilities, and technology sponsors can realise increased predictability in their study planning from protocol design through enrolment strategy. Critical analysis in protocol design Nearly eight out of 10 (78%) […]

December 2, 2022

Broadly neutralizing antibodies (bnAbs) are known to protect against HIV infection. However, there are challenges to triggering bnAbs through vaccination and bnAbs rarely develop during infection. In humans, bnAb-precursor B cells are rather uncommon. Now, a first-in-human test evaluated the […]

December 1, 2022

“Most people probably think that inflammation in the brain is something bad and that you should inhibit the inflammatory system in case of illness. But inflammation doesn’t just have to be negative,” explained Joana B. Pereira, a researcher at Lund […]

December 1, 2022

The risk of developing estrogen receptor (ER)-positive breast cancer increases in post-menopausal women if the gene Esr1 (estrogen receptor 1) is expressed excessively in glandular cells of the breasts, reports a study from the Georgetown Lombardi Comprehensive Cancer Center published […]

December 1, 2022

A study by scientists at The Forsyth Institute has suggested strategies for triggering the body to make new cartilage cells, which could have major implications in regenerative medicine for repairing cartilage injuries and degeneration. In their paper in Science Advances, […]

December 1, 2022

Scientists at the University of Pennsylvania say they have developed a novel optical method that uses a pair of macromolecular phosphorescent probes for the real-time monitoring of cerebral metabolic rate of oxygen consumption (CMRO2), concurrently with cerebral blood flow (CBF) […]

November 30, 2022

WHIM syndrome is a rare, inherited, combined immunodeficiency disease that inhibits the body’s ability to fight infections. In most patients, this is caused by over-signalling of the CXCR4/CXCL12 pathway, resulting in reduced mobilisation and trafficking of white blood cells from […]