The complex networks of fluid-filled tubes and loops that exist in human organs have three-dimensional structures whose connections vary, depending on the organ. How these connections and topology develop during the development of an embryo, remains unclear.
Now, using tissue reconstitution and quantitative microscopy, metrics for organ development have been defined for the first time. In a new study, an international team of researchers provides the necessary tools to transform the field of organoids into an engineering discipline to develop model systems for human development.
