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Increasing the Use of Mass Spec in Biomanufacturing

In October, Chetan Goudar, PhD, vice president at Amgen process development, and his colleagues wrote in Current Opinion in Biotechnology: “Rapid technological advances have significantly improved the capability, versatility, and robustness of mass spectrometers which has led to them playing a central role in the development, characterization, and regulatory filings of biopharmaceuticals.” In fact, MS can be used in more areas of bioprocessing than ever.

This technology “was initially limited to protein characterization where no suitable alternate technologies were available,” Goudar says. “With improvements in equipment sensitivity coupled with reduction in size and complexity, applications have expanded exponentially and now include the entire spectrum of bioprocess development and molecule commercialization.”

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