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How a surprise finding made an Alnylam study one of biotech’s most ‘polarizing’ trials

April 25, 2022

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The results didn’t add up.

BridgeBio Pharma, a young biotech trying to bring its first big drug to market, followed the blueprint of one of the world’s largest pharmaceutical companies. It made a medicine meant to work like the one that company, Pfizer, had developed for a deadly, genetic heart condition. The biotech also designed a similar kind of trial to test it and expected similarly positive results.

What BridgeBio got instead was a shock.

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