We are joined today by Ivan Kairatov, a seasoned biopharma expert with extensive knowledge in technology, innovation, and research and development within the industry. In this interview, we will discuss the ClaraTM 6 Well Cell Culture plates introduced by Porvair Sciences, focusing on their materials, design benefits, suitability for various cell types, applications, and compatibility with high throughput processing and automation.
Can you tell us more about the ClaraTM 6 Well Cell Culture plates introduced by Porvair Sciences? The ClaraTM 6 Well Cell Culture plates are an advanced solution for multi-well medium volume cell culture. They are designed to offer high optical clarity and support easy observation of cell health and density during growth. These plates are optimized for use with both eukaryotic and prokaryotic cells, making them versatile for a wide range of cell culture applications.
What materials are used in the manufacturing of the ClaraTM 6 Well Cell Culture plates? These cell culture plates are manufactured from virgin polystyrene, which ensures high optical clarity. This material choice is crucial for users who need to visually inspect cell health and density with ease throughout the culture process.
How does the high optical clarity of the ClaraTM 6 Well Cell Culture plates benefit users? The high optical clarity allows researchers to easily observe and monitor the cell health and density during growth. This transparency is particularly beneficial for ensuring consistent cell culture conditions and making necessary adjustments in real-time.
What type of cells is the ClaraTM 6 Well Cell Culture plate suitable for? Are they suitable for both eukaryotic and prokaryotic cells? Can they be used for mammalian cell lines? Are they appropriate for culturing yeasts and E. coli? The ClaraTM 6 Well Cell Culture plates are suitable for a broad range of cell types, including both eukaryotic and prokaryotic cells. They are particularly suitable for mammalian cell lines, as well as yeast and E. coli cultures. This versatility makes them an ideal solution for various downstream applications in life science research and biologics development.
What applications can benefit from using ClaraTM 6 Well Cell Culture plates? Can they be used for protein expression? Are they suited for plasmid propagation? How about transfection processes? These plates are suitable for a variety of applications including protein expression, plasmid propagation, and transfection processes. Their design and material properties make them highly effective for these purposes, ensuring reliable and predictable cell culture outcomes.
How does the unique round well design of ClaraTM 6 Well Cell Culture plates benefit cell cultures? Does it help to prevent shear stress and cell damage? Is it particularly helpful for delicate cell lines like CHO and hybridomas? The unique round well design creates a gentle media swirling motion during cell culture, which helps prevent shear stress and cell damage. This feature is especially beneficial for delicate cell lines such as Chinese Hamster Ovary (CHO) cells and hybridomas, promoting healthier and more resilient cell cultures.
What is the internal volume of each well in the ClaraTM 6 Well Cell Culture plate? How much cell suspension can be cultured per well? Each well in the ClaraTM 6 Well Cell Culture plate has an internal volume of 50 mL, which allows for culturing up to 30 mL of cell suspension per well. This capacity is ideal for medium volume cell preparations needed for various downstream applications.
Why is the ClaraTM 6 Well Cell Culture plate ideal for biologics development? Does it support working with challenging molecules such as bispecifics and multi specifics with low expression levels? The design and functionality of the ClaraTM 6 Well Cell Culture plates make them ideal for biologics development, especially for working with challenging molecules like bispecifics and multi specifics that have low expression levels. The plates ensure efficient cell culture conditions that are conducive to the growth and production of these complex molecules.
Can you explain the well geometry’s role in ensuring efficient cell suspension? How does this affect incubation and liquid movement within the wells? Does it facilitate efficient oxygen transfer throughout the culture? The well geometry is carefully engineered to ensure optimal liquid movement within the wells during incubation. This facilitates homogeneous cell suspension and efficient oxygen transfer throughout the culture, ensuring healthy cells and high yields of product. This design promotes reliable and predictable cell growth and protein or plasmid production.
What features make the ClaraTM 6 Well Cell Culture plate suitable for high throughput processing? The ClaraTM 6 Well Cell Culture plates are tailored for high throughput processing. They are designed for ease of handling and are fully compatible with automation, making them suitable for large-scale operations that require efficient processing of multiple samples.
Is the ClaraTM 6 Well Cell Culture plate compatible with automation? What is the benefit of the dual grip point design? Which robotic handling systems can it be used with? Yes, the ClaraTM 6 Well Cell Culture plates are fully compatible with automation. The dual grip point design enhances the versatility of these plates, allowing them to be used with a wide variety of robotic handling systems. This compatibility streamlines workflows and improves efficiency in automated processing environments.
Do the ClaraTM 6 Well Cell Culture plates conform to any industry standards? Is barcoding available for automated sample tracking and traceability? The plates conform to the ANSI/SLAS standard footprint, ensuring compatibility with industry equipment and protocols. They are also available with barcoding options, which facilitate automated sample tracking and traceability, further enhancing their usability in high-throughput and automated settings.
Where can interested users get more information about the ClaraTM 6 Well Cell Culture plates? Interested users can visit Porvair Sciences’ website or contact their team of experts directly for more detailed information about the ClaraTM 6 Well Cell Culture plates and their applications.
Do you have any advice for our readers? For those working in cell culture and biologics development, it’s crucial to choose the right tools that not only meet your immediate needs but also support scalability and automation. Investing in high-quality cell culture plates like ClaraTM can significantly enhance your research outcomes and efficiency.
