AbbVie first bought in to the programme with a $205 million upfront payment five years ago, attracted by the potential to use checkpoint inhibitors to try to reproduce in neurology the sometimes stunning results achieved with the class in oncology.
The deal came as a break from the prevailing amyloid hypothesis, the target of many Alzheimer’s drug candidates that have tried and failed to tackle the disease over the last 25 years but is still the main thrust of drug development for the disease.
