The U.S. Food and Drug Administration approved the combination of tremelimumab (Imjudo) plus durvalumab (Imfinzi) and platinum-based chemotherapy for adult patients with metastatic non-small cell lung cancer with no sensitizing epidermal growth factor receptor mutation or anaplastic lymphoma kinase genomic tumor aberrations.
Both tremelimumab and durvalumab are administered as an intravenous infusion. For patients weighing 30 kg or more, the recommended tremelimumab dose is 75 mg every three weeks with durvalumab 1,500 mg and platinum-based chemotherapy for four cycles, then durvalumab 1,500 mg with maintenance chemotherapy every four weeks. A fifth tremelimumab dose (75 mg) should be given at week 16.
