Groundbreaking research conducted by a collaborative team from Mount Sinai and Memorial Sloan Kettering Cancer Center has unveiled a novel mechanism by which monoamine neurotransmitters, specifically serotonin, dopamine, and histamine, regulate brain physiology and behavior. This research
The field of drug discovery has long been challenged by the concept of "undruggable" targets—proteins and pathways that are crucial in disease processes but difficult to target with traditional small molecule drugs. One particularly challenging target is β-catenin, a key player in the Wn
Autoimmune diseases occur when the immune system erroneously targets the body's own cells and tissues. These diseases usually present a preclinical stage with mild symptoms or specific antibodies detectable in blood tests before the disease fully manifests. However, in some cases, these
Insilico Medicine, a clinical-stage company leveraging generative artificial intelligence (AI) for drug discovery and development, has announced promising results for its novel drug, ISM5411, aimed at treating Inflammatory Bowel Disease (IBD). This gut-restricted and PHD-specific inhibitor was
Glioblastoma, an aggressive and often fatal form of brain cancer, has long posed a formidable challenge to medical professionals. With an average lifespan of 12 to 15 months post-diagnosis and a mere 5% survival rate five years after diagnosis, the need for innovative treatments has never been more
Penn Medicine’s Center for Cellular Immunotherapies (CCI) is at the forefront of revolutionizing cancer treatment through CAR (chimeric antigen receptor) T cell therapy. This innovative approach harnesses the power of the patient’s own immune system to target and destroy cancer cells, offering new h
The detection and segmentation of brain tumors in MRI images present a critical challenge in medical diagnostics, given their implications for patient treatment plans and outcomes. Despite advancements in imaging techniques and manual segmentation methodologies, the need for precise, automated
Acute respiratory infections are a significant cause of both morbidity and mortality in young children globally, with an especially pronounced impact in low- and middle-income countries on children under five years old. Among the array of pathogens responsible for these illnesses, human
Asthma is the most prevalent chronic respiratory disease in children, disproportionately affecting racially and ethnically minoritized populations in the United States. Puerto Rican and non-Hispanic Black youths, in particular, experience higher rates of emergency department visits due to asthma
Researchers at the National University of Singapore (NUS) have developed an innovative method to enhance the effectiveness of chemotherapy while mitigating its adverse side effects. This novel approach employs brief, localized pulses of magnetic fields, which significantly increase the uptake of
