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What Time You Get Your COVID Shot Might Affect Immune Response

December 8, 2021


Can the time of day you get your COVID-19 vaccine affect how many antibodies you’ll make?

A new study suggests that it can.

Researchers found higher antibody levels in health care workers who received their vaccines in the afternoon, and they suggest that response to the vaccine may be affected by circadian rhythms.

“Our observational study provides proof of concept that time of day affects immune response to SARS-CoV-2 vaccination, findings that may be relevant for optimizing the vaccine’s efficacy,” said co-senior study author Dr. Elizabeth Klerman. She’s a research investigator in the Division of Neurophysiology’s Sleep Unit at Massachusetts General Hospital.