Researchers at the University of Michigan (U-M) School of Pharmacy and the Rogel Cancer Center took a different approach to boosting the STING pathway. The team observed that adding the nutritional metal ion manganese to STING agonists boosted STING’s tumor-fighting capability.
Their findings are published in the journal Nature Nanotechnology in a paper titled, “Amplifying STING activation by cyclic dinucleotide–manganese particles for local and systemic cancer metalloimmunotherapy.”
