The phase 2 trial investigated a single administration of Compass Pathways’ proprietary Comp360 formulation of synthetic psilocybin given in tandem with psychological support to 233 subjects with depression that had not responded to antidepressant drugs.
The study tested two doses of the psychedelic drug – 10mg and 25 mg – with a 1 mg dose used as a control group. After three weeks, the 25 mg group saw a statistically significant reduction in Montgomery–Åsberg Depression Rating Scale (MADRS) scores compared to control, while the 10 mg dose showed no significant benefit.
