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Impact of Gut Microbiome and Genes on Blood Metabolome Could Guide Targeted Interventions

November 11, 2022

Via: GEN

Institute for Systems Biology researchers have found that the gut microbiome is partly responsible for the differences in circulating blood metabolites across people. The team studied variability in plasma metabolites in more than 1,500 individuals for whom paired genomic and metabolomics data were available. The results indicated that nearly two-thirds of the more than 900 blood metabolites were largely associated with either genetics or with the gut microbiome, and 70% of those associations were driven solely by the microbiome.

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