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First study to show waning effectiveness of 3rd dose of mRNA vaccines

February 11, 2022

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A nationwide study from the U.S. Centers for Disease Control and Prevention (CDC) is the first to show that immunity against severe COVID-19 disease begins to wane 4 months after receipt of the third dose of an mRNA vaccine (Pfizer or Moderna). Waning immunity was observed during both the Delta and Omicron variant waves in similar fashion to how mRNA vaccine effectiveness wanes after a second dose. Although protection decreased with time, a third dose was still highly effective at preventing severe illness with COVID-19.

Until this study, little was known about durability of protection following three doses, especially during periods of Delta or Omicron predominance in the U.S.

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