Feingold syndrome 1 is a rare, genetic congenital malformation syndrome characterized by microcephaly, and numerous digital anomalies. People with Feingold syndrome 1 are frequently born with a blockage in part of their digestive system called gastrointestinal atresia. A new study using CRISPR genome editing in zebrafish helped to reveal a decrease in protein synthesis in cells of the developing gut contributes to Feingold syndrome 1.
The findings, “Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1,” are published in PLoS Biology and led by Yun-Fei Li of Zhejiang University School of Medicine in Hangzhou, China, and colleagues.
