High performance liquid chromatography (HPLC) and biomanufacturing have a long, interwoven history. HPLC supports every aspect of biotherapeutic discovery, development, and manufacturing, to the point where thinking of biotech absent HPLC becomes difficult. Through their ongoing co-evolution HPLC will assume even greater importance as the analytic engine for Biopharma 4.0.
Advances in HPLC have affected small molecule drugs too, but not to the same degree as for biotherapeutics. “Traditional” HPLC, using larger particles and sub-6000 psi operating pressures, are a mainstay in pharmaceutical quality control, a situation unlikely to change any time soon.
