Choroideremia is an X-linked genetic disease that leads to retinal degeneration and blindness. The disease is marked by a progressive loss of photoreceptors, retinal pigment epithelial (RPE) cells, and choriocapillaris. By combining traditional eye imaging techniques with adaptive optics—a technology that enhances imaging resolution—researchers have shown, for the first time, how cells across different tissue layers in the eye are affected in people with choroideremia.