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Peptide Drugs Braced for Rigors of Oral Route

As far as our digestive system is concerned, peptides are foodstuffs to be broken down, not therapeutics to be kept intact until they enter the bloodstream. Peptide drugs, then, must run a gauntlet of countless degradative enzymes. Few have what it takes to stand the punishment. To give peptide drugs a sturdier backbone, researchers at the Ecole Polytechnique Fédérale de Lausanne (EPFL) have been developing double-bridged peptides, that is, peptides that are cyclized by two chemical bridges.

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