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New Recombineering Method May Overcome Key Obstacle in Genetically Engineering Bacteria

Researchers in the Blavatnik Institute at Harvard Medical School (HMS) and the Biological Research Center in Szeged, Hungary, say they have developed a new genetic engineering technique that promises to transform recombineering methodology.

Their report “Improved bacterial recombineering by parallelized protein discovery” is published in PNAS.

The team created a high-throughput screening technology to look for the most efficient proteins that serve as the engines of recombineering. Such single-stranded DNA-annealing proteins (SSAPs) reside within phages.

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