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New COVID-19 vaccines could target replication proteins

November 12, 2021


The study has been published in Nature. Researchers at University College London, UK, have said that next generation vaccines for COVID-19 should aim to induce a response against ‘replication proteins’, essential for the very earliest stages of the viral cycle.

COVIDsortium analysed the immune responses in a large cohort of healthcare workers in London, from the beginning of the pandemic in March 2020. Some of these healthcare workers appeared to have a low-level infection which was undetectable by routine tests, but which generated T cells specific to SARS-CoV-2. These individuals also had a low-level increase in another blood marker of viral infection.

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