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Muscle Finding Could Lead to New Therapies for Heart Disease and Skeletal Muscle Disorders

Scientists at the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association say they have developed a mouse model that enables them to look inside a working muscle and identify the proteins that allow the sarcomere to contract, relax, communicate its energy needs, and adapt to exercise.

Their study “Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice” appears in Nature Communications.

Specifically, they were able to map proteins in defined subregions of the sarcomere, starting from the Z-disc, the boundary between neighboring sarcomeres. This in and of itself was a significant step forward in the study of striated muscle, according to the team.

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