With treatments for COVID-19 lacking, researchers are homing in on drugs that are already FDA approved to search for candidates that may inhibit SARS-CoV-2 replication. This method, known as repurposing, has found that clofazimine, an anti-leprosy drug, exhibits potent antiviral activities against SARS-CoV-2. Taken together, the data provide evidence that clofazimine may have a role in the control of the current SARS-CoV-2 pandemic and future pandemics caused by coronaviruses.