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Breast Cancer Metastasis Promoted by Regulatory RNAs

A wide variety of cancer types have been linked to the misregulation of long noncoding RNA (lncRNA) genes. Now, a team from Cold Spring Harbor Laboratory (CSHL) showed that a particular lncRNA plays a role in mammary tumor cell proliferation, migration, and invasion, both in vitro and in vivo. In animal experiments, the growth of metastatic tumors was reduced by a molecule designed to target that RNA and trigger its destruction. The work demonstrates that the lncRNA represents a potential therapeutic target to alter breast cancer progression.

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