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Advanced Solid Tumor Prodrug Developed

Solid tumors are notoriously difficult to treat and often put children into a high-risk category as tumors like neuroblastoma, Ewing sarcoma, and rhabdomyosarcoma in these patients often don’t respond to conventional therapies. Chemotherapy given orally or intravenously generally does not deliver enough of the drug to the tumor, which not only renders the chemotherapeutic agent ineffective but also leads to increased drug resistance—combined with the all too common and almost unavoidable side effects such as severe diarrhea, bone marrow suppression, and secondary malignancies. As such, scientists and clinicians are always on the hunt for new drugs or new ways to deliver old drugs to make them more efficacious to patients.

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